Role of E-cadherin Expression in Breast Carcinoma

Cancer of breast has emerged as the leading site of cancer in India. E-cadherin (E-CD) is one of calciumdependent transmembrane glycoprotein mediating cell–cell adhesion. It has its application in differentiating invasive ductal carcinoma not otherwise specified (IDC-NOS) vs invasive lobular carcinomas (ILCs) and predicting the aggressiveness of the tumor. In this study, we intend to see E-CD expression in breast carcinoma by immunohistochemistry (IHC), comparing its status with histological grade and type.